After the Fall of Constantinople, there is a significant presence of either Greek-Orthodox or Islamized Greek architects, such as Sinan. From the mid-16th century the activity of Greek-Orthodox architects significantly intensified, while it is noted that over 40% of the architects in the empire were Christians.

The orthodox churches of Constantinople have a long and turbulent history, as is recorded in sources since the 16th century. They have suffered multiple natural disasters such as earthquakes and fires, while they have also paid a bitter price in all purges of the Greek-orthodox population in the 19th and 20th centuries.

The cemeteries of the Greek-Orthodox population in Constantinople, monuments of the robustness of the Greek Orthodox population at the end of the Ottoman era, are today threatened with extinction. Their preservation is urgently needed, as they constitute quite important monuments of the collective memory of the minority.

After the Fall, many churches in Constantinople were modified into Muslim religious sites. During the follοwing centuries, quite a few churches burned down due to multiple fires. Later on, during the 19th century, at the time of Tanzimat, many orthodox churches were constructed.