1753: Establishment of Constantinople’s first Greek Plague Hospital in Yedi Kule by the grocers’ guild.

1762: Establishment of the Naval Hospital of Galata by the Official of the Porte Georgios Stavrakoglou.

1780: Establishment of Plague Hospital of Stavrodromi.

1794: Common Fund for Hospitals and Prisons under the supervision of five guilds.

1830s: Work for the construction of new hospital in Balukli.

1827: Establishment of the Ottoman Military Medical School.

1837: Establishment of pest house in Constantinople.

1856: Establishment of the Imperial Medical Society.

1860s: Charity Fraternities’ first regulations.

1861: Establishment of Ladies' Charitable Society in Stavrodromi.

1860-1862: Preparation of the "general rules", which institutionalized the Orthodox millet recognizing it as an entity with cohesive organization and function. The hospitals are renamed into “National Charity Establishments” and get under the supervision of the Permanent National Mixed Council.

1862: Publication of A. Paspatis’ book Memorandum for the Greek Hospital of the Seven Castles [Eptapyrgion], a reference work for the notions of hygiene during that period.

1864: Preparation of the Rules of the National Hospital of the Greek-Orthodox in Constantinople. The National Charity Establishments are divided into the main hospital, home for the aged and mental hospital.

1866: Establishment of the under masonic influence Philergos Society with multiethnic composition aiming at the propagation of the ideal of work to the poor irrespective of their ethnic origins.

1870: Preparation of the Organization of the National Orphanage of the Orthodox in Constantinople, as a distinctive part of the Charity Establishments.

1870: Establishment of the Bulgarian Exarchate.

1976: Preparation of the first regulations of an Orthodox community in Constantinople, those of the Greek Orthodox Community in Stavrodromi, followed by the regulations of the communities of Mega Revma (Arnavutköy), Chalcedon (Kadıköy) and, later, Kontoskali. According to those regulations, the communities assume the institutional responsibility for education and philanthropy.

1870s and onwards: Preparation of most of the regulations of the charitable societies, which got under the supervision of community and parish authorities.

1876: A sewing workshop is established by Ladies’ Charitable Society in Stavrodromi. Similar initiatives are taken in other communities too.

1887: Establishment of the Medical Commission for the Abandoned Infants of the Church of the Presentation of Virgin Mary in Pera.

1902: Preparation of the Fundamental Regulation, according to which the Patriarchate and the Permanent National Mixed Council specified officially that philanthropy and education were the main duties of the community and parish authorities.